JCE Software Chemistry Comes Alive!
HIV-1 Protease: An Enzyme at Work

This is "HIV-1 Protease: An Enzyme at Work", from a video tape published by the Journal of Chemical Education - Software as Special Issue 13

HIV-1 Protease: Introduction


Movie View Movie
7 MB
112 seconds

Slides View Slides
8 Slides





 
A way to slow HIV production involves inhibiting the action of a cleavage enzyme that cut a large protein molecule into smaller pieces that are active. Clotting of cow's blood shows the importance of cleavage enzymes.

HIV-1 Protease Monomers


Movie View Movie
3.5 MB
54 seconds

Slides View Slides
3 Slides



     
Active protease has two identical protein molecules called monomers.

HIV-1 Protease: Types of Models


Movie View Movie
6.9 MB
109 seconds

Slides View Slides
9 Slides





 
There are many ways to model a molecule.

HIV-1 Protease: Cutting the Pre-protein - Inhibiting This Cutting


Movie View Movie
5.9 MB
92 seconds

Slides View Slides
5 Slides





 
If an inhibitor molecule is attracted to the cleavage site, it is no longer available to cut the pre-protein and HIV can't reproduce.

HIV-1 Protease: An Inhibitor as Possible Treatment for AIDS


Movie View Movie
4.1 MB
62 seconds

Slides View Slides
4 Slides





 
If a thrombin inhibitor is present in the blood, it doesn't form a clot. A suitable inhibitor could be a treatment for HIV and AIDS.